Posttraumatic Stress Disorder - Our Current Studies

Enhancing Fear Extinction via Angiotension Type 1 Receptor Inhibition: A Randomized Controlled Trial in Posttraumatic Stress Disorder

Study Sponsor: Department of Defense

Study Contact: Sarah Wieman, (617) 726-1570,

Description:The purpose of this research study is to see whether Losartan, a medication FDA-approved and commonly prescribed for the treatment of high blood pressure, may be effective for treating Posttraumatic Stress Disorder (PTSD). After medical and psychiatric evaluations are completed, eligible participants are randomly assigned (that is, by chance) to one of 2 study medications lasting approximately 12 weeks:

  • Losartan
  • Placebo (a surgar pill without active medication)

Key Eligibility criteria:

  • Adults 18 - 70 who have PTSD or Posttraumatic Stress Symptoms
  • PTSD symptoms experienced for at least three months

Participants will be paid $25 upon completion of the intake visit, as well as $25 for each of 7 study assessment visits, for a maximum total of $200.

Please call our phone screen line at 1-866-44-WORRY or email us at for a full phone screen to determine if you would be eligible to come into the clinic to meet with one of the study doctors.


Center for Anxiety and Traumatic Stress Disorders
Massachusetts General Hospital

1 Bowdoin Square, Boston MA 02114

More about the Massachusetts General Hospital

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Contact Us

Center for Anxiety and Traumatic Stress Disorders & Complicated Grief Program

Massachusetts General Hospital, Boston, MA

Phone: 1-866-44-WORRY



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